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It is extensively distributed in the tissue and largely metabolized to inert carboxyprimaquine, the major plasma metabolite, which undergoes further biotransformation to unknown metabolites that are probably more toxic than the parent compound.

The identification of other metabolites in humans has been difficult to pursue because the expected aminophenol metabolites are unstable.

All videos are hosted by 3rd party websites and therefore we have no control over the content of these websites.Breastfeeding may be more protective against the development of premenopausal compared to postmenopausal breast cancer.Although there are a few studies that report a decrease in the risk of breast cancer after only three or more months of breastfeeding, the evidence for risk reduction becomes more consistent with the longer women breastfeed.The investigators propose to study the pharmacokinetics of primaquine in maternal and infant plasma and in breast milk during a 14 day radical treatment of P.vivax.Some inferences about the expected behavior of primaquine in lactation can be drawn from its known pharmacologic properties.

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